The article examines the impact of key megatrends on the transformation of the business environment and modern society. The research is based on the analysis of digitalization, postglobalization, geopolitical restructuring and environmental agenda processes. It is revealed that modern megatrends lead to fundamental changes in the structure of economy, social relations and management practices. Special attention is paid to the influence of the fourth industrial revolution on the formation of new business models and transformation of the entrepreneurial landscape. The conclusion is made about the necessity of complex adaptation of organizations and institutions to new conditions determined by systemic megatrends.